EFFECT OF ALOE VERA EXTRACT ON THE HEPATOTOXICITY INDUCED BY ISONIAZID AND RIFAMPICIN DRUG IN MALE WISTAR RATS

Male Wistar rats were procured from ‘The Bombay Veterinary College’, Parel, Mumbai. The animals were maintained and housed in cages and were acclimatized in laboratory conditions for ten days prior to the experiment. The experimental rats were fed orally with isoniazid 300 mg/ 70 kg body weight / day; rifampicin 450 mg / 70 kg body weight / day and Aloe vera extract 50 mg/ kg body weight / day for 30 days. Blood samples of the above groups (A to H) were taken after 30^th day from cardiac puncture for estimation of mean concentration  serum of AST, ALT, ALP, and ACP, bilirubin, total proein, total albumin and total globulin in serum of rats treated with  Aloe vera, Isoniazid and Rifampicin independently as well as in combinations. In our study the more commonly measured ‘liver’ enzymes are  showing significant increase in the levels of AST, ALT, ALP, and ACP, bilirubin total proein, total albumin and total globulin in serum of rats treated with Isoniazid and Rifampicin individually and in combination when compared with control rats, whereas the levels of AST, ALT, ALP, and ACP, bilirubin, total protein, total albumin and total globulin in serum were found somewhat decreased in rat treated with Aloe vera independently as well as in combination with Isoniazid and Rifampicin drug