EFFECT OF ALOE VERA JUICE ON THE TOXICITY INDUCED BY ISONIAZID AND RIFAMPICIN DRUGS ON COMPLETE BLOOD COUNT IN MALE WISTAR RATSAbstract
Male Wistar rats were procured from ‘The Bombay Veterinary College’, Parel, Mumbai. The animals were maintained and housed in cages and were acclimatized in laboratory conditions for ten days prior to the experiment. The experimental rats were fed orally with isoniazid 300 mg/ 70 kg body weight / day; rifampicin 450 mg / 70 kg body weight / day and Aloe vera extract 50 mg/ kg body weight / day for 30 days. Blood samples of the above groups (A to H) were taken after 30th day from cardiac puncture for estimation of mean concentration of complete blood Count. The present changes resulted from the antitubercular drugs in the hematological changes might be attributed to the toxic metabolites of the isoniazid and rifampicin. The toxic, reactive metabolites of the drugs bind to cellular macromolecules and release or form toxic free radicals intern caused the tissue damage. The present study was concluded that Supplementation of Aloe vera extract resulted in significant improvement in the hematological parameters might be due to its antioxidant, antistress, cytotoxic, antioxidant, hypoglycemic and anti-inflammatory properties.
P. P. Bhise and G. V. Zodape *
Departments of Zoology, S.S. & L.S. Patkar College of Arts and Science & V.P. Varde College of Commerce and Economics, S.V. Road, Goregaon (West), Mumbai, Maharashtra, India
16 April, 2016
30 May, 2016
13 June, 2016
01 September 2016