EFFECT OF ANTINEOPLASTIC LOADED TRANSDERMAL PATCH IN DMBA-INDUCED BREAST CANCERAbstract
Background: The current study assessed the effect of an Antineoplastic-loaded transdermal patch in Dimethyl-benzanthracene (DMBA)-induced breast cancer. Materials and Methods: Different formulations composed of various concentrations of tamoxifen citrate, poly (SA: RA), glucose, and mannitol were formulated and evaluated in DMBA-induced breast cancer in female albino Wistar rats. Multiple parameters were evaluated, such as body weight, hemoglobin content, red blood cell, white blood cell, SGPT, and SGOT. Results: Treatment with formulations showed a decrease in body weight compared to disease. Equally, a considerable increase in hemoglobin was observed in the formulation-treated group over the disease grouping. Likewise, there is a decrease in SGPT and SGOT in formulation compared to disease. Conclusion: The present study revealed a transdermal patch loaded with tamoxifen showed promising antitumor activity.
Chandra Shekhar Sharma *, Prashant Kumar and Anurag Verma
Department of Pharmaceutics, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.
02 September 2022
11 December 2022
14 February 2023
01 March 2023