EFFECT OF CURCUMIN SUPPLEMENTATION ON THE SUBMANDIBULAR SALIVARY GLANDS OF D-GALACTOSE INDUCED MALE MICEAbstract
Significant increase in the salivary gland lipid peroxidation, fluorescence product as well as accumulation of lipofuscin granules–age pigment was observed after injection of 5% D-galactose 0.5 ml daily for 30 days. Supplementations of turmeric extract (30mg/kg body weight) for 30 days during and after D-galactose treatment significantly reduced all the above parameters. Histochemical changes in the form of accumulation of age pigment were observed in the submandibular gland (SMG) of experimental animals. The normalization of levels of all the studied parameters in the SMG by curcumin supplementation in D-galactose induced aging accelerated mice is suggestive of the possible ameliorating effect of curcumin on SMG. While in curative group II the levels of all parameters were elevated as compared to D-galactose treated group mice.
M.V. Walvekar, P.P. Sarvalkar* and S.B. Pol
Department of Zoology, Shivaji University, Kolhapur, 416004, Maharashtra, India
11 August, 2012
12 September, 2012
24 November, 2012
01 December, 2012