EFFECT OF FRUIT JUICE ON THE DISSOLUTION OF DICLOFENAC SODIUM SUSTAINED RELEASE MATRIX TABLETSAbstract
In vitro dissolution of ten brands of diclofenac sodium sustained release matrix tablets were studied to determine the effect of fruit juice in the bioavailability of diclofenac. Significant reduction was observed in the release rate at all collected brands, where except sample D7 and D8 others were not fulfill the USP in vitro dissolution specification when administered with fruit juice. Therefore to avoid drug therapeutic failures and of the drug in the systemic circulation, ingestion of the juice with diclofenac sodium should be discouraged.
Mycal Dutta , Aninda Kumar Nath , Md Zia Uddin Md Akbar Hossain Md. Masud Morshed and Md. Hassan Kawsar*
Associate Professor, Department of Pharmacy, Dhaka International University, Dhaka-1213, Bangladesh
23 June, 2011
04 October, 2011
24 November, 2011
01 December, 2011