EFFECT OF FUROSEMIDE (LOOP DIURETIC) ON INGESTIVE BEHAVIOR, BODY WEIGHT AND CERTAIN HEMATOLOGICAL PARAMETERS IN ADULT WISTAR RATSAbstract
The present experiment was aimed to examine the effect of furosemide (loop diuretic) on ingestive behavior & some hematological parameters. The adult Wistar rats (n=6/ group) were divided into control group (n =6; Group I) and experimental group (n =6; Group II). The experimental group received furosemide intraperitonially (40mg/kg BW) for a duration of 30 days. The control group of rats was injected with distilled water of same volume intraperitonially. Body weight, food and water intake was measured each day. At the end of the experimental procedure; blood samples were collected to measure the hematological parameters such as total leukocyte count (TLC), blood cell (RBC) count , Packed cell volume (PCV) and hemoglobin (Hb) concentration. The results were analyzed statistically by using student‘t test. P < 0.05 was considered as significant. Our present results showed that, administration of furosemide showed a significant increase (P < 0.001) in the ingestive behavior and body weight. Further, the RBC count, PCV, Hb concentration also showed a significant increase (P < 0.05) whereas the TLC showed a significant decrease (P < 0.05). The present data suggests that furosemide intake alters the ingestive behavior, body weight and causes the variations in observed hematological parameters.
Venkappa S. Mantur , N. A. Vinodini*, A. K. Nayanatara , A. V. Ranade , C. Ramaswamy , Pratik K. Chatterjee and K. Kishan
Associate Professor in Physiology, Department of Physiology, Center for Basic Sciences, Kasturba Medical College, Bejai, Mangalore- 575004, Karnataka, India
07 November, 2011
06 December, 2011
21 February, 2012