EFFECT OF GALANTAMINE WITH NEUROPHARMACOLOGICAL BENEFITS IN WISTAR RATS MODELS OF EPILEPSY AND BEHAVIOURAbstract
Involvements of oxidative damage, deficiency of acetylcholine and cognitive impairment have been reported in the pathophysiology of epilepsy. It has been demonstrated that cholinesterase is degranulated at the site of a lesion it cause brain disorder leading to epilepsy. Cholinesterase inhibitor (Galantamine) inhibits the release of cholinesterase thus it benefits in epilepsy. So the aim of the study was to evaluate both effect cholinesterase inhibitor (Galantamine) and cognitive behaviour in epilepsy induced by increasing current electroshock seizures test of Wistar rats. Epilepsy was evaluated by behavioural tests such as spontaneous alternation behaviour and Rota rod test. Measurement of oxidative stress was done by various biochemical estimations namely lipid peroxides (in brain), protein estimation using Folin’s reagent and brain reduced glutathione estimation. All the results of galantamine (0.5 mg/kg & 1 mg/kg) were compared to the standard drug sodium valporate (100 mg/kg & 200 mg/kg).
N. Tyagi *, V. Singh and M. Junaid
School of Pharmaceutical Science, Shri Venkateshwara University, Gajraula, Amroha, Uttar Pradesh, India.
03 March, 2018
13 May, 2018
15 May, 2018
01 November, 2018