EFFECT OF INDUCTION CHEMOTHERAPY ON VITAMIN D LEVEL IN CHILDREN WITH ACUTE LEUKEMIAAbstract
Background: Subnormal level of vitamin D are associated with the higher frequency of cancer and correlated with inferior prognosis in some cancers; no data exist for acute leukemia. Aim of the work: To clarify the relationship between serum vitamin D levels and acute leukemia in children. Materials and Methods: Vitamin D level was measured in sixty-six pediatric patients who are newly diagnosed with acute leukemia in Central Child Teaching Hospital during a period between March 5th to August 30th, 2017 and normal 50 children were considered as the control group. Information on the patients were obtained from the medical files of the patients. Patients were classified on a random base as active patients group how the received daily requirement of vitamin D during induction chemotherapy period and passive patients’ group who were treated with chemotherapy only. Vitamin D level was reassessed at the time of remission. Results: The serum vitamin D level in children with acute leukemia was below normal ranges; at the time of diagnosis, the mean of serum level was 13 ng/dl, while in the control group was 21 ng/dl. There was a statistical difference between the patient’s group and the control group (p-value 0.001). At the time of remission, serum vitamin D level decreased to 11.8 ng/dl in the passive patients’ group and increased in active patients group to 17.1 ng/dl. Conclusion: vitamin D level was low in a majority of pediatric patients with acute leukemia, and it was further reduced after induction-remission in patients without vitamin D replacement.
H. H. Ghali, R. A. Sabri, A. I. A. Mohammed and S. A. Faraj *
Department of Pediatrics, College of Medicine, Wasit University, Kut, Iraq.
24 May 2019
01 October 2019
03 February 2020
01 March 2020