EFFECT OF IVNT ON OVARIAN WEIGHT, FOLLICLE NUMBER, ESTRUS FREQUENCY AND REVERSIBILITY OF REPRODUCTIVE CYCLE IN ALBINO RAT

The cyclic albino rats of body weight group (120-130 gm.) were intravaginally treated with single dose (0.1 ml) neem oil at various durations to study its anti-fertility efficiency. It was observed that a significant increase in ovarian weight in weekly three months treated rat group to control and a significant decrease in follicle numbers in single ovary in weekly and fortnightly one and three months treated rat group in comparison to control.  The disturbed reproductive cycle showed a highly significant increase estrus frequency from control in case of weekly and fortnightly one and three month treated rat group. But in rat group treated for monthly one and three months showed a significant increase. The reversibility showed a highly significant decrease in fortnightly one month in comparison to weekly one month treated rat group whereas monthly one month treatment showed a significant decrease from fortnightly one month treated group. The fortnightly three months treatment showed a significant increase in the reversibility with weekly and monthly three months treated group. All such findings might be an indication of antifertility efficacy of neem oil through intravaginal routs of treatment which affects hypothalemo-pituitary-ovarian axis and through cell mediated immune reaction and monthly three months treatment showed a better reversibility therefore this may through light on the way and duration of IVNT is highly applicable.