EFFECT OF MAGNESIUM STEARATE ON MUCOADHESIVE MICROSPHERES OF REPAGLINIDE
AbstractIn this study, an attempt was made to prepare Mucoadhesive microspheres of Repaglinide using various Mucoadhesive polymers designed for oral controlled release. Microspheres containing the Mucoadhesive polymer chitosan hydrochloride, with matrix polymer Eudragit RS 100, Repaglinide as a model drug and agglomeration preventing agent magnesium stearate were prepared by the Emulsification solvent evaporation method. The amount of magnesium stearate is varied and the following methods were used for microspheres evaluation: drug content, dissolution determination, scanning electron microscopy and FTIR spectroscopy. The microspheres were evaluated for surface morphology and particle shape by scanning electron microscope. The microspheres were also evaluated for their microencapsulation efficiency, in vitro wash-off mucoadhesion test, and in vitro drug release. The microspheres were found to be spherical and free flowing. The microencapsulation efficiency was in the range of 61.44±1.16 to 78.90±1.17and microspheres exhibited good mucoadhesive property in the in vitro wash off test. The drug-polymer concentration of dispersed phase influences the particle size and drug release properties.
Article Information
13
111-118
634 kB
1291
English
IJPSR
Vimal K. Yadav*, S. K. Prajapati, Alok Mahor and Brajesh Kumar
Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India
19 July, 2010
09 October, 2010
15 November, 2010
http://dx.doi.org/10.13040/IJPSR.0975-8232.1(12).111-18
01 December, 2010
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