EFFECT OF MOISTURE CONTENT OF EXICIPIENT (MICROCRYSTALLINE CELLULOSE) ON DIRECT COMPRESSIBLE SOLID DOSAGE FORMSAbstract
Quality of pharmaceutical product is very important because pharmaceuticals drugs should be safe and therapeutically active formulation performance should be consistent and predictable. Final product quality depends on all ingredients which is used for making the final product tablet. Final product tablet is made by the addition of bulk drug and excipients. The continuous evolution of the bulk drugs and excipients can only ensure the quality of final product. Moisture content of API’S and excipients plays a very important role to manufacture the final product. It is may affect the physical and chemical properties of final product. Moisture content affects the physical, chemical and microbiological properties of pharmaceutical finished dosage forms. In direct compression process, high and extra low moisture content could be it affects the hardness of tablet. For satisfactory hardness of tablet, room temperature and humidity must be maintained in a specific limit. Tablet hardness is also most import parameter for any solid dosage form.
Monika Tomar *, Singh Ajay Kumar and Sinha Amit Raj
Sigachi® Industries Private Limited, Dahej SEZ Gujarat, India
18 July, 2016
01 September, 2016
13 September, 2016
01 January, 2017