EFFECT OF MURVA (MAERUA OBLONGIFOLIA) ON ALLOXAN INDUCED DIABETES IN RATSAbstract
Diabetes is a chronic metabolic disorder characterized by altered carbohydrates, fat and protein metabolism, and an increased risk of vascular complications. Swiss albino mice weighing 20-25g and albino rats (Wistar strain) weighing 170-190g of either sex were used for the studies. Mice used for toxicity and rats for anti-diabetic study. The aqueous roots extract of Murva was found to be safe at a dose of 2000mg/kg; hence a dose of 800mg/kg was used for anti-diabetic study. Diabetes was induced by alloxan monohydrate 150mg/kg i.p. After three days of injection of alloxan, diabetes was confirmed by monitoring its blood glucose level. Animals with blood glucose level more than 200mg/dl were taken for studies. Glibenclamide 20mg/kg i.p was taken as std. drug. The test possessed significant anti-diabetic activity (p<0.001) when compared to positive and negative control. Hence the roots extract of Murva may be value in patients with diabetes mellitus.
C. N. Arulanandraj*, T. Punithavani and S. Indumathy
Lecturer, Department of Pharmaceutical Analysis, Mother Theresa Post Graduate & Research Institute of Health Science, Gorimedu, Puducherry- 605006, India
06 June, 2011
24 August, 2011
29 September, 2011
01 October, 2011