EFFECT OF NATURAL AND ARTIFICIAL SUPERDISINTEGRANTS IN THE FORMULATION OF FAST DISSOLVING DICLOFENAC TABLETAbstract
FDTs are designed to disintegrate rapidly on contact with saliva and enables oral administration without water or chewing, these formulations offer increased convenience and ease of administration with the potential to improve patient compliance, particularly in certain populations, where swallowing of conventional solid oral dosage forms presents difficulties. In the present study, the effect of a natural superdisintegrant Fenugreek and synthetic superdisintegrants sodium starch glycolate (SSG) was compared in the formulations of fast dissolving tablets (FDT). FDTs of Diclofenac (model drug) were prepared by direct compression method. These tablets were evaluated for weight variation, hardness, thickness, disintegration time, water absorption ratio, friability and dissolution. Swelling index was also investigated with an aim to compare the swelling property of Fenugreek with Sodium starch glycolate (SSG). Fenugreek showed higher swelling index than SSG. Hence, the present study revealed that this natural superdisintegrants showed better disintegrating property than the most widely used synthetic superdisintegrants like SSG.
Chanda Ray* and Vandana Arora
Lloyd Institute of Management & Technology, Mahamaya Technical University, Greater Noida, Uttar Pradesh, India
19 June, 2012
17 July, 2012
23 September, 2012
01 October, 2012