EFFECT OF NICORANDIL ON BLOOD GLUCOSE LEVEL IN NORMAL RATSAbstract
Nicorandil is occasionally given for cardiovascular disorders in patients also suffering from diabetes mellitus. Simultaneous use of nicorandil and sulfonylureas may interfere with the euglycemia. The study was done to find the effect of nicorandil on glucose tolerance in normal male Wistar albino rats, under oral glucose load, adrenaline injection and in receiving oral hypoglycemic drugs. Male albino rats 100-120g was divided into control and treatment groups. The control group of rats received either oral 2% gum acacia or normal saline subcutaneously. The treated groups received either glucose (1g/100g), glipizide (0.045mg/100g) or nicorandil (0.18mg/100g) orally alone or in combination. Blood samples were collected from lateral tail vein at 0, 1, 2 and 4hrs interval. Blood glucose estimation revealed that nicorandil significantly reduced glucose tolerance in normal rats and in rats made hyperglycemic by oral glucose load or adrenaline injection. It antagonized the hypoglycemic effect of glipizide and reduces glucose tolerance in rats at human therapeutic dose.
Arunava Biswas*, Sabnam Ara Begum , Balaram Ghosh , Syed Mohammed Naser , Manab Nandy and Sudeb Mondal
“The Water Side”, Block C, Flat No. 5E, 170F, Nilgunj Road, Kolkata- 700114, West Bengal, India
24 March, 2013
30 April, 2013
21 July, 2013
01 August, 2013