EFFECT OF ORAL ADMINISTRATION OF VITAMIN A ON BLOOD GLUCOSE LEVEL IN RABBITS AND ITS POSSIBLE INTERACTIONS WITH COMMONLY USED ORAL ANTIDIABETIC AGENTSAbstract
In diabetes mellitus antioxidant vitamins are commonly employed to prevent or mitigate the long term complications of the disorder. Diabetic retinopathy, nephropathy, coronary and cerebral vascular insufficiency are examples of such complications. They are more common in Type 2 diabetes mellitus. The present study was conducted to observe the effect of Vit A on blood glucose level and its possible interactions with commonly prescribed oral antidiabetic agents i.e. glimepiride, gliclazide and metformin. The study was performed on healthy albino rabbits of either sex in which hyperglycemia was induced by giving oral glucose. We observed that Vit.A significantly lowered the blood glucose level but antagonized the effect of oral antidiabetic agents in co-administration therapy. It is therefore advisable that caution must be exercised when giving high doses of VitA to produce antioxidant effects in diabetic patients because it is not only unnecessary but may also have potentially deleterious effect on glycemic control.
Chandra Veer Singh and Rakesh C. Verma *
Pharmacology, Academic Block, UP Rural Institute of Medical Sciences & Research, Saifai, Etawah, Uttar Pradesh, India
07 February, 2016
27 April, 2016
05 May, 2016
01 June 2016