EFFECT OF PERMEATION ENHANCER ON EX-VIVO PERMEATION OF ONDANSETRON HCl BUCCAL TABLETSAbstract
The objective of the paper is to study the effect of a permeation enhancer, sodium taurocholate on permeation of Ondansetron HCl from bioadhesive buccal tablet formulation by performing ex-vivo permeation experiments using porcine buccal mucosa. Optimized formulation has selected based on in-vitro drug release studies of bilayered bioadhesive buccal tablets. To the optimized formulation, 10mM sodium taurocholate was added to increase the permeation of poorly permeable ondansetron HCl. It is well known that natural surfactants like bile salts increase the permeability of drugs by perturbation of intercellular lipids. The results indicated that, from pure drug solution (5 mg/mL) about 88.63% cumulative percentage of drug permeated across porcine buccal mucosa with flux of 0.0235 mg.h-1cm-2. However, the optimized formulation with sodium taurocholate increased flux (0.0523 mg.h-1cm-2) and cumulative amount of drug permeated (65.44%) in comparison to formulation without permeation enhancer (38.45%, 0.0186 mg.h-1cm-2) with enhancement ratio of 2.81.
M. Praveen Kumar*, M. Rajendra Prasad, M. Pramod and V. Prabhakar Reddy
Department of Pharmaceutics, St.Peter’s Institute of Pharmaceutical Sciences, Vidyanagar, Hanamkonda-506001, Andra Pradesh, India
14 July, 2011
17 August, 2011
14 October, 2011
01 November, 2011