EFFECT OF PIPER NIGRUM (LINN.) ON INFERTILITY INDUCED BY ETHIONAMIDE AND PARA AMINO SALICYLIC ACID IN MALE SPRAGUE-DAWLEY RATSAbstract
Tuberculosis is a global problem. The tuberculosis is the common cause of male infertility in developing countries due to the use of second-line anti-tuberculosis drugs (ATB). The experiments were conducted at Unique Bio diagnostic Enterprise Veterinary Pathology Laboratory Parel, Mumbai for chemiluminescence immunoassay to study the levels of testosterone in male Sprague-Dawley rats. The histological analysis was also carried out to confirm the study. From the study it was found that the body weights are inversely proportional to the weight of the testis. It was also found that Ethionamide administered rats showed lowest levels of testosterone, which may lead to infertility. To increase fertility potential we have administered Piper nigrum (Linn.) (PnS) seed ethanolic extract in combination with Ethionamide (ETH) + Para aminosalicylic acid (PAS) drugs. From the above results it is found that Piper nigrum increases the level of testosterone by maintaining the fertility potential in male Sprague-Dawley rats, it is also confirmed that the histological reconciliation of testis was appreciably restored in Sprague-Dawley rats administered with Piper nigrum.
G. V. Zodape * and V. S. Gaikwad
Department of Zoology, S.S. & L.S. Patkar College of Arts and Science & V.P. Varde College of Commerce and Economics, Goregaon (West), Mumbai, Maharashtra, India.
02 February 2019
09 October 2019
20 October 2019
01 November 2019