EFFECT OF QUERCETIN AND NERVE GROWTH FACTOR ON BIOCHEMICAL PARA-METERS OF THE BRAIN TISSUE IN RATS WITH EXPERIMENTAL NEURO-DEGENERATIVE DISORDERAbstract
The work was initiated to induce a toxic model of a neurodegenerative disorder with Alzheimer’s disease symptoms in rats and to study the effect of quercetin, an anti-oxidant, and nerve growth factor on some biochemical parameters and parameters of behavioral performance of the animals. It was established that upon induction of the neurodegenerative disorder by an intranasal administration of aluminum chloride and lypo-polysaccharide, there was a decline in motor-sensor, emotional/motivation and cognitive parameters of the animals’ behavioral performance. An increase in the neutral and some fractions of glycolipids, as well as changes in phospholipid profile, were found; the activity of the antioxidant system enzymes with the MDA increase in the hippocampus of the animals was found to decrease. The deviations above in the biochemical parameters of the animals’ hippocampus seem to be a cause for the changes in the animals’ behavioral performance. Intranasal administration of the anti-oxidant and NGF in the liposomal form partially restored the parameters of the animals’ behavioral performance and the biochemical parameters to the control values. Thus, quercetin and NGF seem to prevent further damage of cells in the hippocampus of animals under study and stimulate the undamaged nerve cells.
T. M. Ishankhodjaev *, B. R. Zainutdinov, M. A. Mustafakulov, E. A. Ibragimova, Z. Z. Ibragimov, S. U. Irgasheva, N. I. Mamadalieva and T. S. Saatov
Institute of Biophysics and Biochemistry Under Mirzo Ulugbek National University of Uzbekistan, 174 University Town, Olmazor District, Tashkent, Republic of Uzbekistan.
17 October 2019
07 February 2020
14 March 2020
01 October 2020