EFFECT OF VITAMIN E ON BLOOD GLUCOSE LEVEL IN RABBITS AND ITS POSSIBLE INTERACTION WITH COMMONLY USED ANTI DIABETIC AGENTSAbstract
Effect of Vit. E on blood glucose and its possible interactions with oral antidiabetic agents (i.e. glimepiride, gliclazide and metformin) in rabbits have been reported in the present study. The study was performed on albino rabbits in which hyperglycemia was induced by giving glucose. We observed that Vit.E significantly lowered the blood glucose level but on co-administration with oral antidiabetic agents it antagonized the effect of the latter drugs. It is therefore advisable not to give inadvertent amount of Vit.E to diabetic patients just in a belief that antioxidants are helpful to diabetics and do not produce adverse effects.
Chandra Veer Singh and Rakesh C. Verma *
Pharmacology, Academic Block, UP Rural Institute of Medical Sciences & Research, Saifai, Etawah, Uttar Pradesh, India
31 January, 2016
27 April, 2016
05 May, 2016
01 June 2016