EFFECTIVENESS OF TENDER COCONUT WATER (COCOS NUCIFERA L) AGAINTS PARASITEMIA INDEX AND HEMOGLOBIN LEVELS IN MALARIA INFECTION

Red blood cells (RBCs) is the primary target of human Plasmodium. Species. Occurs oxidative stress on uninfected and infected RBC and lead to hemoglobin (Hb) level decreased. The mechanism of decreased hemoglobin level are reduced survival time, diserythropoiesis and increased erythrolysis. Ascorbic acid and phenolics of TCW effectives to prevent RBCs from oxidative damage. Methods: The post test only randomized control group desain in 30 Swiss mices inoculated with PbA separated in 2 control groups K(+) and K(+)DHP, 4 groups of treatment X1, X2, X3 and X4. TCW treatments of 1mL and 2mL per 100g BW. Statistical analysis uses for parasitemia index and Hb levels was one way ANOVA test. Correlation of both variabel analyzed using Pearson’s test. Results: There were differences of the parasitaemia index (p<0.05) and mean±SD (%)  K(+) (20.46±9.43), K(+)DHP (0.28±0.33), X1 (14.86±5.82), X2 (1.26±1.94), X3 (4.40±1.45) and X4 (0.32±0.40).  There were significant differences in Hb levels (p<0.05) and mean±SD (g%)(8.46±1.36, 11.92±1.16, 9.92±1.77, 11.04±1.92, 11.06±0.80 and 12.80±1.16),  multiple range test shown the differences of K(+) againts K(+)DHP and X4, p <0.05. Parasitemia index and Hb levels was significantly correlated, (p<0.05) and (r -0.724). Conclusion: Tender coconut water is effective to reduce the parasitaemia index and increase hemoglobin levels in mice inoculated Swiss PBA and there is negative correlation among parasitemia index and Hb levels in malaria infection mice.