EFFECTS OF ALOE VERA ON LIVER OF SWISS ALBINO MICE AGAINST SUBLETHAL DOSE OF GAMMA RADIATIONAbstract
The radioprotective effect of Aloe vera was studied in liver of Swiss albino mice. Animals were divided into three groups. Animals of group I administered double distilled water only, group-II Aloe vera (drug) and control set of group III were given radiation only where as animals experimental set of group III were administered by Aloe vera + Radiation. Animals were given Aloe vera leaf extract orally 1000 mg/kg body weight/day for 15 consecutive days before radiation exposure (4.5 GY gamma-radiation).Biochemical parameters such as LPO, GSH, protein, glycogen and cholesterol were assessed at different intervals of post-irradiation i.e. day 1 and 30. Radiation treatment showed decrease in GSH content and an increase of LPO, protein, glycogen and cholesterol observed in control set animals, however the animals of experimental group i.e. Aloe vera and radiation combined group showed a significant increase in GSH content and decrease in LPO, protein, glycogen and cholesterol but values remained below normal. Results suggest that Aloe vera modulate the radiation induced biochemical alterations in Swiss albino mice.
Department of Zoology, Biyani Girls College, Jaipur, University of Rajasthan, Rajasthan, India
16 March, 2015
29 April, 2015
21 June, 2015
01 October, 2015