EFFECTS OF GLYCOSMIS PENTAPHYLLA LEAF POWDER AGAINST CHRONIC ARSENICOSIS IN RATSAbstract
The present study was undertaken to evaluate the effects of Glycosmis pentaphylla (GP) leaf powder against sodium arsenite (NaAsO2) induced toxicosis in adult albino rats. Forty eight albino rats having body weight 150-200 gm of either sex were randomly divided (equally) into four groups viz., I0, I1, I2, I3. Sodium arsenite was administered at 4mg/kg body weight daily in drinking water for 90 days to all rats of groups I1, I2 and I3. The rats of group I2 and I3 were orally treated with leaf powder of G. pentaphylla at 500mg/kg and 250mg/kg (1/10th of and 1/20th of LD50) daily from 91st day to 120th day. Distilled water was given to rats of I0 for 120 days and rats of I1 for 91st day to 120th day. Blood samples were collected at different days for analysis of haemogram, biochemical parameters like ALT, AST, BUN and CRT. Tissue samples were collected to study activity of SOD, MDA, GSH, catalase and histopathology was conducted after completion of experiment. The results reveal that the G. pentaphylla leaf powder may mitigate the arsenicosis in rats at dose dependent manner and in future may be used to reduce or to prevent arsenic toxicity in human
Amartya De *, Sarmila Nath, A. K. Das, S. K. Bandyopadhyay , M. C. Banerjee and T. K. Mandal
BCDA College of Pharmacy and Technology, Hridaypur, Barasat, Kolkata, India.
18 October, 2016
05 February, 2017
20 April, 2016
01 May, 2017