EFFECTS OF POLY-UNSATURATED FATTY ACIDS ON LEUKOCYTE TELOMERE LENGTH AND INFLAMMATORY MARKERS IN D-GALACTOSE TREATED WISTAR ALBINO MALE RATSAbstract
The present study aimed at analyzing the effects of PUFA in D-galactose treated Wistar albino male rats by determining leukocyte telomere length using real-time quantitative PCR, Il-6, and high sensitive C-RP levels estimation using ELISA. D-galactose is administered for 42 days orally (100 mg/kg), and on 43rd-day, blood is collected from tail vein and plasma is separated and subjected for IL-6 and high sensitive C-RP estimation using ELISA and determination of length of leukocyte telomere by real time qPCR. PUFA had no significant influence on length of leukocyte telomere and it decreased significantly IL-6 and high sensitive C-RP levels, indicating possible anti-aging effects by decreasing inflammation associated with aging process.
B. S. Sriram, V. Ravichandra *, S. Moodithaya, R. Holla and N. S. Kumari
Department of Pharmacology, K. S. Hegde Medical Academy, Mangalore, Karnataka India.
16 February 2020
26 May 2020
30 May 2020
01 February 2021