EFFICACY AND MECHANISM OF ACTION OF MORINGA OLEIFERA IN DIABETESAbstract
Diabetes mellitus (DM) is a globally spreading metabolic disorder with a high incidence rate. About 425 million cases took place in 2017 and expected to rise up to 693 million by 2045. In diabetes, the patient elevation of blood glucose level occurs due to the deformation of insulin receptor action/secretion or both. Long term increases in blood glucose level causes chronic effects such as dysfunction and damage of various organs such as eyes, nerves, kidney heart and blood vessels. There are many treatment regimens available in market, but do not able to provide complete relief and cause severe side effects. To overcome these types of problems it becomes important to find different therapeutic targets and use it in combination with conventional medicine for the treatment of diabetes. To surmount the side effect of presently available treatments, now researchers relay on herbal plants. In this review, we discussed the diabetes occurrence, epidemiology, types, different target receptors, and available treatments and describe briefly role of different plant constituents in diabetes management and focused on a main plant, Moringa oleifera.
Sneha, M. Kaurav and S. Kumar *
Department of Pharmaceutical Sciences, Indira Gandhi University, Meerpur, Haryana, India.
09 December 2019
24 March 2020
26 March 2020
01 September 2020