EFFICIENCY OF A COST-EFFECTIVE UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF CIPROFLOXACIN HCL IN MARKETED TABLET FORMULATIONAbstract
A simple, reproducible and economical UV spectrophotometric method was developed for determining the potency of ciprofloxacin HCl in tablet dosage forms marketed in Bangladesh. Standard curves of ciprofloxacin HCl in the media of 0.1N HCl and distilled water were obtained by plotting absorbance versus concentration where calibration curve was found to be linear (r2>0.99). The average potency value for seven tablet samples (C1, C2, C3, C4, C5, C6 and C7) measured by HPLC method was 99.08±0.60% for 0.1 N HCl taking the absorbance at 277nm and 98.76±0.69% in case of distilled water at 276 nm, whether the value determined by this UV spectrophotometric method was quite satisfactory being 98.15±0.76% and 97.64±0.71%, respectively. In a separate experiment, efficiency of this method in practice was checked by determining the thermostability of ciprofloxacin HCl to find out how severely that degrades in high temperature conditions. Development of such economical UV spectrophotometric method will encourage low-investing pharmaceutical companies to employ this alternative method in quality control laboratories for routine analysis of ciprofloxacin HCl.
Sultana Rajia, Imtiaj Hasan, Ruhul Amin and Md. Anwar Ul Islam*
Department of Pharmacy , University of Rajshahi, Rajshahi , Bangladesh
20 March, 2015
30 April, 2015
23 June, 2015
01 October, 2015