ELLAGITANNIN EXTRACTED FROM PLANT EUPHORBIA PROSTRATA CLAIM MEMORY ENHANCING ACTIVITYAbstract
Human memory can store and recall previously learned information to be applied for the routine purpose. Memory disorders caused by diseases can have an impact on an individual’s quality of life as well as their overall cognitive abilities. Memory disorders are associated with the alteration in cholinergic neurotransmission. The herbal extract of Euphorbia prostrata was found to be used traditionally for the maintenance of memory-related disorders, but the active constituent and its mechanism were still unrevealed. Thus, in the current study, a ligand library was prepared with some potential lead molecules from the plant Euphorbia prostrata and was computationally screened to identify the most potent ligand responsible for the memory enhancement effect as establishing the probable mechanism of action involved in it. Ellagitannin was found to be the most potent ingredient of the Euphorbia prostrata plant, which is supposed to have a memory enhancement effect. Ellagitannin is supposed to exert its therapeutic effect via an agonistic effect on the muscarinic receptor, muscarinic acetylcholine G-protein coupled receptor, N-methyl-D-aspartate receptor, as well as antagonizing acetylcholinesterase enzyme.
Nirmala Kumari Yadav and Rakesh Yadav *
School of Pharmacy, National Forensic Sciences University, Gandhinagar, Gujrat Tripura Campus, Agartala, Tripura, India.
04 October 2022
28 November 2022
30 November 2022
01 June 2023