EMULGEL: AN EMERGENT TOOL IN TOPICAL DRUG DELIVERYAbstract
|In comparison among the other groups of semisolid preparations, the use of gels has been emerged both in cosmetics and in pharmaceutical preparations because of its unique array of features. Despite of providing several benefits the category gel faces limitations in delivering hydrophobic drug molecules via skin. So in order to cover up this lacking a recent emulsion based approach is being used so that even a hydrophobic therapeutic moiety can enjoy the unique properties of gels. The use of gels and emulsions as combined dosage form results into formation of emulgel showing dual release. With this approach the use of polymers with enhanced effect in release pattern has been emerged providing sustained and controlled release. The presence of a gelling agent in the water phase converts a classical emulsion into an emulgel. These emulgels show major advantages on novel vesicular system as well as on conventional systems in various aspects. Emulgels have several favourable properties for dermatological use such as being thixotropic, greaseless, easily spreadable, easily removable, emollient, nonstaining, long shelf life, bio-friendly, transparent and pleasing appearance. So emulgels can be used as better topical drug delivery systems over present systems. The use of emulgels can be expanded in analgesics, anti-inflammatory, anti-fungal, anti-acne drugs and various cosmetic formulations. This review gives knowledge about Emulgel including its properties, advantages, formulation considerations, and its recent advances in research field.
Anu Hardenia*, Sonali Jayronia and Sanjay Jain
Smriti College of Pharmaceutical Education, 4/1 Pipliya Kumar Kakad, Maya Khedi Road, Indore 452010, (MP), India.
20 November, 2013
20 February, 2014
09 March, 2014
01 May, 2014