ENHANCEMENT OF DISSOLUTION RATE OF CIPROFLOXACIN BY USING VARIOUS SOLID DISPERSION TECHNIQUES
AbstractThe aim of this research wok is to formulate and evaluate Ciprofloxacin solid dispersions system by using the different techniques. This will increase the solubility of the drug or Ciprofloxacin and give the immediate release of the drug from the formulations. The main objective is to formulate a drug product as immediate release oral solid dosage form of Ciprofloxacin solid dispersion system which is considered to be stable, robust quality and enhanced dissolution rate. To optimize the method of manufacture by formulate the Ciprofloxacin solid dispersion system by various techniques like Physical mixing, Co-grinding, Kneading and solvent evaporation techniques. The disintegrating agent used in the present study is Crosscarmellose sodium. Among the four different techniques used for preparation of solid dispersions solvent evaporation technique has shown the increase in dissolution rate that is the Trail-5 was found to have a faster solubility and dissolution property which was prepared by using Crosscarmellose sodium as a disintegrant in the ratio of 1:1.
Article Information
36
4376-4383
563KB
1751
English
IJPSR
Brahmaiah Bonthagarala*, Leela Madhuri Pola and Sreekanth Nama
Department of Pharmaceutics, Priyadarshini Institute of Pharmaceutical Education & Research (PIPER), 5th Mile, Pulladigunta, Kornepadu (V), Vatticherukuru (M), Guntur-522017, Andhra Pradesh, India
brahmaiahmph@gmail.com
26 June, 2013
14 August, 2013
25 October, 2013
25 October, 2013
01 November, 2013
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