ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF BCS CLASS II DRUG RITONAVIR USING LIQUISOLID TECHNIQUE
AbstractBCS class II drugs usually suffer inadequate bioavailability as a dissolution step is the absorption rate-limiting step. In this work, the effect of solubility increase at the main absorption site for these drugs was investigated using ritonavir as a drug model. The liquidsolid technique was applied to prepare ritonavir per-oral tablets of high dissolution rate using versatile non-ionic surfactants of high solubilizing ability [Transcutol HP, labrasol and labrasol/labrafil (1:1) mixture] as liquid vehicles at different drug concentrations (10–30%) and fixed (R). The prepared liquisolid tablets were fully evaluated, and the dissolution rate at pH 1.2 was investigated. The formula of higher dissolution rate was subjected to solid state characterization using Differential Scanning Calorimetric (DSC), Infrared Spectroscopy (IR). Results showed that liquisolid tablet prepared using labrasol/labrafil (1:1) mixture as a liquid vehicle containing 10% ritonavir is a compatible formula with a higher dissolution rate (100% in 35 min). This led to the conclusion that liquisolid technique efficiently improved the drug solubility and dissolution rate of BCS class II drugs.
Article Information
46
2430-2438
912
1534
English
IJPSR
B. Bonthagarala, V. Dasari * and V. Kotra
Department of Pharmaceutics, Sri Indu Institute of Pharmacy, Sheriguda (V), Ibrahimpatnam (M), Ranga Reddy, Telangana, India.
varundrd@gmail.com
05 September 2018
17 April 2019
19 April 2019
10.13040/IJPSR.0975-8232.10(5).2430-38
01 May 2019
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