ENHANCEMENT OF SOLUBILITY OF POORLY SOLUBLE DRUG BY INCLUSION COMPLEXATION WITH γ-CYCLODEXTRINAbstract
Candesartan is an angiotensin receptor blocker, used as an anti-hypertensive drug. It is available in the salt form of cilexetil i.e.; Candesartan cilexetil belongs to class II of the Biopharmaceutical classification system. It is a poorly soluble drug, and the bioavailability is 15%. The intention of the study is to improve the solubility of the poorly soluble drug, Candesartan cilexetil using the inclusion complexation technique with γ-CD as a complexing agent. Complexation is the association between two or more molecules to form a non-covalent-based complex that has a higher solubility than the drug itself. Binary mixtures of Candesartan cilexetil were prepared with three different techniques (Physical Mixture, Kneading method, Solvent evaporation method)in three different ratios (1:1, 1:2, 1:3). The prepared complexes were analyzed using Fourier transform infrared spectroscopy. In-vitro dissolution studies were performed for all the prepared complexes by different methods in different ratios in order to define the most appropriate ratio and preparation method.
B. Radha Madhavi *, B. Divya, K. Anusha, G. Tejaswi, G. Yamini Divya Teja and K. Kiran Kumar Reddy
Department of Pharmaceutics, Shri Vishnu College of Pharmacy, Vishnupur, Bhimavaram, West Godavari, Andhra Pradesh, India.
25 January 2021
03 May 2021
29 May 2021
01 December 2021