ESTIMATION OF ORLISTAT BY UV SPECTROPHOTOMETRIC METHODAbstract
A simple, reproducible and efficient spectroscopic method developed and validated for determination of Orlistat in bulk and capsule dosage form. The drug was determined spectrophotometrically at 203 nm using methanol as a solvent. The percentage recovery study of the drug for the proposed method ranges from 100.17-99.53%w/w indicating no interferences of the capsule excipients. Linearity was obtained in the concentration range 10-100μg/ml with correlation coefficient of 0.9982. The result analysis was validated statistically and recovery studies confirmed the accuracy and precision of the proposed method.
T. Hemant Kumar*, K. Manasa Reddy, D. Rishika and R. Prasanna Kumar
Department of Pharmaceutical Analysis, Greater Hyderabad Institute of Pharmacy, Ibrahipatnam, R. R. Dist, Andhra Pradesh, India
30 May, 2011
15 August, 2011
23 August, 2011
01 September, 2011