ETHANOLIC LEAF EXTRACT OF PREMNA TOMENTOSA AMELIORATES ALCOHOL INDUCED HEPATOTOXICITY IN ALBINO RATSAbstract
Alcoholic liver disease (ALD) comprises a wide variety of damage, starting from steatosis to liver cancer. ALD results from a multifactorial interaction between behavioral, ecological and hereditary factors. This study aimed to evaluate the hepatoprotective effect of ethanolic extract of Premna tomentosa (EEPT) on ethanolic toxicity liver. The characterization of EEPT extract was performed using standard biochemical analysis. Thirty-six male albino Wistar rats were divided into 6 groups; Hepatotoxicity was induced using 40% ethanol (1ml/100gm b.w) for 10 days. Group I received distilled water. Group II, III, IV, V were administered with 40% ethanol (1 ml/100gm); Group III and IV was given EEPT (500 and 750 mg/kg, b.w), Group V receives Ayurvedic drug (Liv 52 1ml/100gm) and Group VI was given EEPT (500 mg/kg) for forty-five days. Total body weight, wet weight of the liver, serum total bilirubin, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase was compared and assessed statistically. EEPT of 500 and 750 mg/kg shows a significant (p<0.01) reduction of liver enzymes, it shows the protection against ethanol-induced hepatotoxicity.
T. Gomathipriyadharsini *, M. Kavimani, S. Sathiyanarayanamurthy and K. Prabhu
Bharath University, Department of Anatomy, Vivekananda Dental College for Women, Thiruchengode, Namakkal, Tamil Nadu, India.
03 July 2019
03 November 2019
08 February 2020
01 May 2020