ETHOSOMES – A PROMISING WAY FOR TRANSDERMAL DRUG DELIVERY
AbstractOne of the major advances in vesicle research was the finding that some modified vesicles possessed properties that allowed them to successfully deliver drugs in deeper layers of skin. Transdermal delivery is important because it is a noninvasive procedure for drug delivery. Further, problem of drug degradation by digestive enzymes after oral administration and discomfort associated with parenteral drug administration can be avoided. An alternative approach to overcome the low oral bioavailability is to administer the drug by non oral routes such as buccal, nasal, vaginal, transdermal and parenteral. Among the above routes the transdermal delivery of ethosome is advantageous. Because it has good penetrability, ease of administration, rapid termination of the therapy and administrating to unconscious patients. Ethosome mainly contain phospholipids with higher concentration of ethanol. It can be used for systemic delivery of drug. It is beneficial to overcome the problem of frequent dosing due to shorter half-life of drugs. Prolonged release of the drug and increased bioavailability leads to significant reduction in the dose and hence dose related side effects
Article Information
3
3663-70
421
1935
English
Ijpsr
Sunisha Kulkarni*, Kaushal Prasad Mishra, Shyam Bihari Sharma and Suman Jain
S. O. S. In Pharmaceutical Sciences, Jiwaji University, Gwalior, Madhya Pradesh, India
sunishakulkarni2007@gmail.com
13 February, 2015
25 May, 2015
22 August, 2015
10.13040/IJPSR.0975-8232.6(9).3663-70
01 September, 2015
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