ETODOLAC DISSOLUTION IMPROVEMENT BY PREPARATION OF SOLID DISPERSIONS WITH CYCLODEXTRIN COMPLEX’SAbstract
Etodolac is an anti-inflammatory drug that is poorly soluble in water. This paper describes an approach to improve the dissolution rate of Etodolac by using solid dispersions (SDs) in hydrophilic polymers. The solid dispersions prepared with a Co-evaporation, kneaded method & Physical Mixture method using different concentrations of α-cyclodextrin (α-CD). The release of Etodolac from various solid dispersions was determined from dissolution studies by use of USP dissolution apparatus. The dissolution study results revealed that there was a considerable increase in solubility of all solid dispersions as compared to pure drug. Prepared solid dispersions were characterized by DSC, PXRD, IR and SEM images were evaluated for drug content, saturation solubility. Physicochemical characterization of solid dispersions suggests a reduction in drug crystallinity following dissolution enhancement. Results indicate that present % DE 30 of drug was improved from 36.01 to 58.57 by the use of Etodolac α-CD-HPMC (1:2:0.3) Kneaded complex.
R. Pilli *, M. V. Nagabhushanam and S. D. V. S. K. Kadali
Department of Pharmaceutics, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India.
16 April 2014
20 June 2014
31 July 2014
01 November 2014