EVALUATE THE EFFECT OF BACOPA MONNIERI, EVOLVULUS ALSINOIDES AND TINOSPORA CORDIFOLIA ON BIOCHEMICAL PARAMETERS IN RATS BRAINAbstract
Bacopa monnieri, Tinospora cordifolia, and Evolvulus alsinoides are conventional Ayurvedic floras that are useful in the various neuropharmacological ailment. This research focused on the effect of ethanolic extract of Bacopa monnieri (BME), Tinospora cordifolia (TCE), and Evolvulus alsinoides (EAE) were evaluated alone and in a combination of extracts (CEPs) by using scopolamine-induced oxidative stress in rats. Tissue homogenates were prepared, an indicator of Superoxide Dismutase (SOD), Glutathione (GSH), Lipid peroxidation (LPO), Catalase (CAT) and Acetylcholinesterase (AChE) enzyme activities were estimated in the rat brain. Due to scopolamine treatment, enhanced LPO and AChE level but reduced SOD, CAT, and GSH levels in rats brain were observed. Rats treated with BME, TCE, EAE, and their CEPs [CEP-1 (EAE and BME), CEP-2 (TCE and BME), CEP-3 (TCE and EAE) and CEP-4 (BME, TCE, and EAE)] at 200 mg/kg, provided significant effect against scopolamine because these extracts decreases LPO, AChE level and restored SOD, GSH, and Catalase levels in rats brain. The CEPs produced significant effects in comparison to BME, TCE, and EAE. Thus, these results demonstrate that BME, TCE, and EAE in CEPs provide significant protective potential against Scopolamine induced oxidative stress.
A. Gupta *, M. P. Singh and S. S. Sisodia
Department of Pharmacology, Bhupal Nobles’ College of Pharmacy, Bhupal Nobles’ University, Udaipur, Rajasthan, India.
16 August 2019
06 November 2019
04 March 2020
01 July 2020