EVALUATING ADJUNCTIVE ROLE OF PPI AS ANTI INFLAMMATORY AGENT IN KNEE OSTEOARTHARITIS: A PROSPECTIVE STUDY IN TERTIARY CARE HOSPITALAbstract
Osteoarthritis (OA) is one of the main causes of disability worldwide. Patients are mostly treated with NSAIDS with PPI and H2 blockers, analgesics, opoids etc in everyday practice. In addition to anti-secretory effects, PPIs have anti-oxidant and anti-inflammatory actions in vitro. But the role of PPIs as anti-inflammatory agents remains to be explored. Aim: Present study was aimed to compare efficacy and safety of Diclofenac (DIC) + Proton pump inhibitor(PPI) and Diclofenac+H2 blocker in patients with knee osteoarthritis methodology: We conducted prospective randomised control open label study on 40 patients at Orthopedic OPD of tertiary care hospital. Patients were given either DIC(100mg SR OD) + PPI (Omeprazole 20mg OD) or DIC (100mg SR OD)+ H2 blocker (Famotidine 20mgOD) for two weeks. Clinical effectiveness was assessed by using Knee injury and Osteoarthritis Outcome Score (KOOS) and Visual analogue score(VAS) as efficacy parameters. Suspected ADRs were recorded at each visit. Observation: In the present study, the prevalence of osteoarthritis was more common in the age group 50-59 years (48%) with female predominance (95%). After application of KOOS questionnaire and VAS net quality gain in symptoms were better with SR diclofenac +PPI group than SR diclofenac+H2 blockers. Less ADR profile were seen in diclofenac +PPI group with epigastric pain topping the list. Conclusion: Addition of PPI act not merely as potent acid suppressing agents but also add to the anti-inflammatory and analgesic action of diclofenac and increases patients adherence / compliance to the treatment.
Mehwish Majeed * and Yogita S Karandikar
Department of Pharmacology, Government Medical College, Srinagar, Kashmir, India
22 December, 2015
03 April, 2016
04 May, 2016
01 June, 2016