EVALUATING HYPOLIPIDEMIC POTENTIAL OF KASNI SEED (CICHORIUM INTYBUS) PREPARATIONS IN NEWLY DIAGNOSED PATIENTS OF METABOLIC DISORDERAbstract
Objective: To evaluate hypolipidemic potential of Kasni (Cichorium intybus) seed preparations combined with oral hypoglycemic agent in treatment of patients of newly diagnosed type 2 DM. Methods: Newly diagnosed 90 patients of Type2DM, age 35-65years, of either sex were divided into 3 groups. Each group having 30 patients (19 male and 11 females) matched with each other in terms of age and sex. In group I only Glycomet SR once a day and in group II/III 6 grams crude seed powder or 50 ml decoction of crude seed powder twice a day in combination with Glycomet SR once in a day, was given for 90 days. Serum cholesterol, triglyceride, LDL and HDL levels were measured at zero, 30th, 60th and 90th day. Results: All the three groups showed a significant reduction in cholesterol, triglyceride and LDL across the four time periods. Post hoc Tukey HSD test shown that there was a significant difference between group I & II (p=0.045) and group I & III (p=0.000) for cholesterol; group I & II (p=0.008) and group I & III (p=0.000) for triglyceride and I & II (p=0.032) and group I & III (p=0.001) for LDL. While there was a significant increase found in HDL level. Conclusions: The add on therapy with Kasni seed preparations is more effective as hypolipidemic agent than only oral hypoglycaemic agent in decreasing serum cholesterol, triglyceride and LDL levels of selected patients. Among Kasni seed preparation treated groups, decoction was found better than crude seed powder.
Praveen Katiyar * , Amod Kumar , Arvind K. Mishra , Rakesh K. Dixit and Ajay K. Gupta
Department of Pharmacology & Therapeutics , King George's Medical University, Lucknow, U.P., India
14 March, 2015
05 May, 2015
23 August, 2015
01 September, 2015