EVALUATING THE COST OF ILLNESS AND HEALTH-RELATED QUALITY OF LIFE IN CLINICALLY DEPRESSED PATIENTS: A PILOT STUDY
AbstractMental disorders, particularly depression, substantially affect health by impairing daily functioning and lowering quality of life (QoL). This study assessed the relationship between depression severity, QoL, and cost of illness among 51 depressive patients. Regression analysis showed that age was the only significant demographic factor influencing QoL (β = -0.433, p = 0.043), while other factors, such as gender and education, showed no significant effects. A strong negative correlation was observed between depression severity and all QoL domains of WHOQOL-BREF (total r = -0.970, p< 0.001), indicating that QoL decreases markedly with increasing depression severity. One-way ANOVA further confirmed significant differences across severity groups (F = 63.20, p< 0.001). Cost analysis revealed a significant negative correlation between QoL and indirect costs (r = -0.472*, p = <0.001), suggesting that higher financial burden—especially from productivity loss was associated with poorer QoL. Overall, the findings emphasise that advancing age, greater depression severity, and increased indirect economic burden significantly reduce the quality of life in depressive patients.
Article Information
21
1888-1894
554 KB
2
English
IJPSR
Aditya Parashar * and Piyush Mittal
Department of Pharmacy Practice, Teerthankar Mahaveer College of Pharmacy, Teerthankar Mahaveer University, Moradabad, Uttar Pradesh, India.
adyt909@gmail.com
03 January 2026
23 January 2026
24 January 2026
10.13040/IJPSR.0975-8232.17(6).1888-94
01 June 2026
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