EVALUATING THE EFFECT OF EXTRACT OF HALELA SIYAH (TERMINALIA CHEBULA RETZ) ON CHEMICALLY INDUCED CATALEPSY IN MICEAbstract
The objective of the present study was to evaluate the anticataleptic effect of Halela siyah (Terminalia chebula Retz) extract, on haloperidol induced catalepsy in swiss mice which were divided into four groups of six animals each. Animals in different groups were administered distilled water, scopolamine (1.0 mg/kg p.o) and hydroxy alcoholic (3:7) extract of Halela siyah (Terminalia chebula Retz), 1.5gm/kg and 3gm/kg p.o. respectively. Catalepsy was induced with haloperidol (1.0 mg/kg i.p.) administered 30 minutes prior to the drug administration. The duration of cataleptic time in the animals was assessed at 30 minute intervals up to 120 minutes and at the end of 240 minutes. Haloperidol induced catalepsy test was carried out for single dose study and after seven days of drug administration, to assess time and dose dependent effect of the test drug. The results showed that after the haloperidol administration, Halela siyah (Terminalia chebula Retz) extract in different doses was effective in reducing the cataleptic time significantly (p<0.01) in a time and dose dependent manner. The present study indicated that Bisfaij facilitates dopaminergic transmission and possibly acts as D2 receptor agonist and hence can be developed as an alternative/adjuvant drug in preventing and treating the extrapyramidal disorders.
Pervaiz Ahmad Dar*, G. Sofi and M. A. Jafri
Department of Ilmul Advia, IAMS Zakura, Srinagar, Jammu & Kashmir, India
24 April, 2012
14 July, 2012
29 July, 2012
01 August, 2012