EVALUATING THE EFFECTS OF COMMIPHORA MOLMOL (MYRRH) AGAINST OXIDATIVE DNA DAMAGE IN HUMAN LYMPHOCYTESAbstract
Oxidative stress is a condition that might predispose individuals to diseases, including cancer. The 8- hydroxydeoxyguanosine (8-OHdG) is an index that reflects DNA damage caused by oxidative stress in the body. In this study, Commiphora molmol (Myrrh) (C. molmol) (Myrrh) that belongs to the family Burseraceae were investigated for its potential favorable properties to blunt DNA damage induced by oxidative stress employing 8-OHdG assay using human lymphocyte cultures. Lymphocytes were separated from blood samples collected from healthy volunteers, cultures, and incubated in aqueous extract of C. molmol (Myrrh) at 0, 10, 100, and 1000 µg/ml. Extracts at 10,100 and 1000µg/mL from the oleo-gum resin of C. molmol (Myrrh) significantly decreased levels of 8-OHdG. The oleo-gum resin of C. molmol (Myrrh) medicinal plants can be used as useful agents to counteract oxidative DNA damage in cultured cells. Collectively, the data revealed that oleo-gum resin of C. molmol (Myrrh) possesses favorable antioxidants and therefore lends support to its therapeutic application.
H. M. Daradka *, H. A. Aljohani, M. K. Alotaibi, O. Flah Khabour, A. A. Eskandrani, S. M. Alsharif, R. Al-Shdefat, H. A. Abu-Harirah and Y. Bataineh
Biology Department, Faculty of Science, Taibah University, B.O. 344, Al-Madinah Al-Munawwarah, Saudi Arabia.
16 June 2020
22 October 2020
14 December 2020
01 June 2021