EVALUATION AND COMPARISON OF HEPATOPROTECTIVE ACTIVITY OF LIVSPLIN SYRUP AND LI- VERVE TONIC FORMULATIONS AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN RATSAbstract
Liver diseases are a worldwide problem. Conventional drugs used in the treatment of liver diseases are sometimes inadequate and can have serious adverse effects like mild digestive problem, headache, nausea etc. It is necessary to search for alternative drugs and for treatment of liver disease to replace currently used drugs of doubtful efficacy and safety. Herbal therapies are free from side effects and toxicity, unlike allopathic medicines. Ayurvedic drugs are also acts by multiple pathways and shown full protection in liver disorders. Composition of marketed formulation Livsplin syrup (Test A) and Li- verve tonic (Test B) containing different plant extracts reported hepatoprotective and antioxidant activities. Thus these formulations may be synergistically or additively may show beneficial hepatoprotective activity with allopathic medicines. Hence, it may useful as alternative medicine to cure different kinds of liver diseases in man and animals. From our investigation, results were shown that administration of Li – verve tonic effectively protected against the loss of antioxidant activities of SOD, CAT, MDA respectively compared to control group and it is well known to serve diverse biological functions, protection of cells from oxidative damage by Reactive oxygen species & free radicals.
N. M. Kagadi *, P. L. Ladda and N. S. Naikwade
Department of Pharmacology, Appasaheb Birnale College of Pharmacy, Sangli, Maharashtra, India.
10 September 2019
04 January 2020
04 March 2020
01 August 2020