EVALUATION OF ALOE BARBADENSIS MILL. GEL ON LETROZOLE INDUCED POLYCYSTIC OVARIAN SYNDROME (PCOS) RAT MODEL- A DOSE DEPENDENT STUDYAbstract
Aim of the present study was to investigate the dose dependent effect of Aloe vera gel [5 mg, 10 mg, 15 mg of dry weight for 60 days each group] on Polycystic Ovarian Syndrome (PCOS) rat model. Charles Foster adult female (200-225 g weight) rats were treated orally with letrozole (non-steroidal aromatase inhibitor) at a dose of 0.5 mg/kg body weight daily for 21 days for PCOS model development, that were further treated orally daily with Aloe vera gel (AVG) at various doses of [5 mg, 10 mg, 15 mg of dry weight for 60 days. Parameters that were evaluated included glucose tolerance profile, estrus cyclicity, ovarian steroidogenic enzymes activities along with hormonal profile (Insulin, Progesterone, Testosterone, and Estradiol). Treatment of AVG daily at doses of 10 mg and 15 mg for 60 days in PCOS rat model demonstrated most beneficial effect by restoring the ovarian steroid status, by modulation of key steroidogenic activities, along with structural changes. This could be attributed to phyto-components present in the extract. The preliminary study explores the effective dose of Aloe vera gel extract as a possible therapeutic agent in prevention and management of such type of infertility.
M. Radha, N. Padamnabhi and N. Laxmipriya*
Assistant Professor Department of Biochemistry Faculty of Science, The M S University of Baroda, Sayajigunj, Vadodara- 390 002. Gujarat, India.
05 May, 2014
27 June, 2014
14 August, 2014
01 December 2014