EVALUATION OF AMELIORATIVE EFFECT OF SYZYGIUM CUMINI LEAVES ON ULCERATIVE COLITISAbstract
Ulcerative colitis is a subtype of Inflammatory Bowel Disease. The leaves of Syzygium cumini belonging to the family Myrtaceae were selected to evaluate its efficacy in ameliorating the acetic acid-induced Ulcerative colitis. Male albino Wistar rats were randomly divided into five groups. Group 1 was given the vehicle tween 80, group II received 2 ml of 4% acetic acid solution on 8th day intrarectally, group III was given 2 ml of 4% acetic acid solution once intrarectally on 8th day and 2mg/kg of prednisolone orally for 3 days starting from the day of acetic acid treatment. Group IV and V received 7 days pretreatment with 250 mg/kg and 500 mg/kg of ethanolic leaf extract of Syzygium cumini (SCEL), respectively, and 2 ml of 4% acetic acid solution once intrarectally on 8th day. Drug treatment was continued till 10th day. The rats were sacrificed on the 11th day, and the hematological, macroscopical and biochemical parameters were assessed. Pre-treatment with the extract improved the hematological parameters, body weight, and the stool consistency score as compared to the positive control.
J. Deepa *, B. Prasanth, Joy L. Mary and B. Sini
Nirmala College of Pharmacy, Muvattupuzha, Eranakulam, Kerala, India.
08 July 2019
16 December 2019
17 April 2020
01 June 2020