EVALUATION OF ANALGESIC ACTIVITY OF ETHANOLIC EXTRACT OF CAPPARIS MOONII WIGHT FRUITS IN SWISS ALBINO MICEAbstract
Medicinal plants abound with many phytochemicals that are effective in representing lots of pharmacological activities. The current study aimed at investigating the phytochemical and pharmacological activity of Ethanolic extract of Capparis moonii Wight. The analgesic activity was examined by Eddy’s hot plate method and the acetic acid-induced writhing method. In Eddy’s Hot plate method, after oral administration of EECM at doses of (50, 100, and 150 mg/kg body weight), at the end of the experiment i.e., at 120 min, the percent MPA was 137.70 ± 2.511, 166.99 ± 2.511 and 211.83±10.648% respectively; whereas the reference drug Pentazocine displayed 288.54±10.379% MPA at the dose of 10 mg/kg as compared to the control, and the results were statistically significant (p < 0.01). In the acetic acid-induced writhing test, after oral administration of EECM at doses of (50, 100, and 150 mg/kg body weight), the percent inhibition was 27.08±1.098, 47.62±4.113, and 71.75 ± 3.127%, respectively. In contrast, the reference drug Ibuprofen displayed 77.70±1.180% inhibition at the dose of 100 mg/kg as compared to the control and the results were statistically significant (p < 0.01). The analgesic effect of the plant in both models suggests that they have been acting through a central and peripheral mechanism.
G. Vanita Kanase * and Vishwavibhushitam Yadav
Department of Pharmacology, Oriental College of Pharmacy, Sector 2, Behind Sanpada Railway Station, Sanpada West, Navi Mumbai, Maharashtra, India.
20 August 2021
24 September 2021
11 October 2021
01 May 2022