EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF SYNTHESIZED AGENTS USING UGI MULTICOMPONENT REACTIONAbstract
In the present study, analgesic and anti-inflammatory activities of the synthesized agents derived from Ugi four component reactions (Ugi-4CR) has been described. The synthesized novel Ugi derivatives 7 (a-h) were characterized on the basis of I.R, 1H NMR and mass spectral analysis. Healthy Wistar Albino rats were used to carry out these activities. Analgesic activity was evaluated by Eddy hot plate method using Morphine Sulfate as a standard reference drug. Anti-inflammatory activity was evaluated by mercury displacement method using Diclofenac as standard reference drug. The results were expressed as mean ± S.E.M. The data were statistically analyzed by Student’s t test and P<0.05 were considered as significant. The screening data shows that synthesized compounds possess potential analgesic and anti-inflammatory activities.
Ipsita Mohanram* and Jyotsna Meshram
Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India
13 February, 2013
15 March, 2013
29 May, 2013
01 June, 2013