EVALUATION OF ANALGESIC & ANTI-INFLAMMATORY PROPERTY OF POLYHERBAL FORMULATION IN WISTER RAT

Introduction: Currently used analgesic agents are opioids & NSAID. All of these are associated with certain adverse effects, so research in new potent herbal formulations is urgently needed. Therefore a polyherbal formulation from seven well-known herbs that had been already individually tested for its analgesic & anti-inflammatory property was prepared, thinking that synergistically it would act better. Aims & objective: To evaluate the analgesic & anti-inflammatory properties of polyherbal formulation (PHF) in Wister rats. Materials and Methods: Analgesic activity was evaluated by using Eddy’s hot plate method & acetic acid-induced abdominal writhing test. Anti-inflammatory activity was tested by using inj. carrageenan-induced hind paw edema test. 24 Wister rats were divided into four groups, viz. A to D. group A served as the control, B & C as test drug group & group D as standard. Results: PHF had shown a significant increase in the hotplate latency period (p<0.01) in a dose-dependent manner, indicating central analgesic property. PHF had also shown a significant reduction in acetic acid-induced abdominal writhes (p<0.01), indicating peripheral analgesic property in it. PHF in 600 mg/kg dose has significant central & peripheral analgesic property & results are comparable with modern drug diclofenac. PHF had also shown a significant reduction in hind paw edema induced by carrageenan injection, indicating anti-inflammatory action too. Conclusion: PHZ has potent analgesic & anti-inflammatory action, which supports its clinical use.