EVALUATION OF ANTI-ALZHEIMER’S ACTIVITY OF ALCOHOLIC EXTRACT OF CISSUS QUADRANGULARIS STEMS IN WISTAR ALBINO RATS

Alzheimer’s disease is the most frequent cause of dementia worldwide and its incidence is increasing due to the world’s aging population. Alzheimer’s disease (AD) is one of the greatest medical care challenges of our century and is the main cause of dementia and neurodegenerative diseases. Dementia is defined as an acquired loss of cognition in many cognitive domains. Herbal medicine has evolved as the greatest option for the treatment of Alzheimer’s disease due to its wide availability, low cost, high patient compliance, ease of formulation and lack of harmful side effects. Novel techniques can be used for the development of herbal medicine. In these research article animal studies, has been carried out to known Alzheimer disease (AD) caused by chemical compounds may be helpful in deeper understanding the mechanism of disease and AD treatment. In the present study, the efficacy of an ethanolic extract of Cissus quadrangularis stems (EECQ) was evaluated against scopolamine-induced Alzheimer’s in the Wistar albino rat. As Cissus quadrangularis stems contain many active chemical constituents, including phenolic compounds, flavonoids, phytosterols, triterpenoids, Vitamin C, Tannins, and alkaloids, etc., serve as useful antioxidants are present in this plant. The Cissus quadrangularis stems were reported to have antioxidant properties. The stem of the Cissus quadrangularis contains carotene mainly β-carotene, which is responsible for showing the anti-Alzheimer’s activity. The antioxidant potential is the best supplement for the diseases associated with oxidative stress. Hence, an attempt was made to evaluate the anti-Alzheimer activity from Cissus quadrangularis stems to extract.