EVALUATION OF ANTI-ANXIETY ACTIVITY OF ACHYRANTHES AASPERA LEAVESAbstract
Anxiety is one of the main psychiatric disorders worldwide. Furthermore, it is difficult to find out the patients suffering from various kinds of anxiety diseases. Numerous herbal plants have been utilized to treat the anxiety disease in traditional medical systems for thousands of years because of their safety, efficacy, and effectiveness. The present study was designed to evaluate the anti-anxiety activity of the hydroalcoholic extracts of the leaves of the Achyranthes aspera plant in rodents like mice. The anti-anxiety activity was assessed in swiss albino mice. The leaf of the Achyranthes aspera plant was air-dried and was reduced to coarse powders. The Soxhlet extraction method was used for this anti-anxiety activity. Qualitative phytochemical screening of hydroalcoholic extracts of Achyranthes aspera was carried out. Several models were used to evaluate the anti-anxiety activity of the leaves of the Achyranthes aspera plant: the elevated plus-maze model, the light-dark model, the social interaction model, and the hole board technique. For this, the dose of hydroalcoholic extract p.o. at 300 and 600 mg/kg, respectively, was selected, and diazepam was used as a standard anxiolytic agent. According to the findings, hydroalcoholic extracts of Achyranthes aspera leaves exhibited diminished aversion fear induces anti-anxiety activity. The hydroalcoholic extracts of Achyranthes aspera leaves were found to have anti-anxiety action. The data indicates that the hydroalcoholic extract of Achyranthes aspera leaves has more anti-anxiety action than the control.
Rajkumar Mathur *, Amul Mishra, Sandeep Yadav and Sazid Ali
Department of Pharmaceutical Sciences, B. N. University, Udaipur, Rajasthan, India.
05 October 2021
24 November 2021
27 June 2022
01 July 2022