EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF MINOCYCLINE: AN EXPERIMENTAL STUDY
AbstractObjective: Evaluation of anti-inflammatory activity of Minocycline: an experimental study. Background: Recently some studies have shown that minocycline may have pleiotropic biologic activities besides its antimicrobial activity. Due to these actions, minocycline may be useful in the treatment of pathological conditions in which acute or chronic inflammation is involved, such as rheumatoid arthritis, neurodegenerative and dermatological diseases. Methods: Wistar rats of either sex weighing 180-250 g were used for evaluating anti-inflammatory activity of minocycline (100mg/kg i.p.) by carrageenan induced rat paw edema and formalin induced arthritis models were used. Results: Minocycline in the dose 100mg/kg showed statistically significant anti-inflammatory activity in both acute and chronic model of inflammation i.e. Carrageenan- induced pawoedema and Formalin – induced arthritis model respectively. Conclusion: Minocycline possesses anti-inflammatory activity. However, further studies need to be carried out to evaluate its anti-inflammatory activity.
Article Information
28
2231-2235
2220 KB
4
English
IJPSR
Mangal K. Choure *, Y. P. Galphade and Rushikesh P. Patil
Department of Pharmacology, Government Medical College, Dharashiv, Maharashtra, India.
drmangalchoure15@gmail.com
23 February 2026
01 April 2026
23 April 2026
10.13040/IJPSR.0975-8232.17(7).2231-35
01 July 2026
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