EVALUATION OF ANTI ULCER ACTIVITY OF AEGLE MARMELOS LEAVES EXTRACTAbstract
The objective of present study is to evaluate the anti ulcer activity of methanolic extract of leaves of Aegle marmelos. The cause of ulceration in patients is mainly due to hypersecretion of gastric juice and pepsin. In traditional system of medicine a number of herbal preparations have been used for the treatment of peptic ulcers. The anti-ulcer activity of methanolic extract of Aegle marmelos leaves was investigated by aspirin plus pylorus ligation induced gastric ulcer in rats, Indomethacin induced ulcer in rats, water immersion stress test induced ulcer in rats. In aspirin plus pylorus ligation model, Aegle Marmelos at doses of 200 and 400 mg/kg produced significant reduction in gastric volume, free acidity and ulcer index compared to control. In Indomethacin and water immersion stress test induced ulcer models both doses (200mg/kg & 400mg/kg) of Aegle marmelos extract significantly reduced severity of ulceration. This present study indicates Aegle marmelos leaves extract have potential anti ulcer activity.
Ashoka M. Shenoy*, Rajnikant Singh, Rajan Moses Samuel, R. Yedle and A.R. Shabraya
Department of Pharmacology, Srinivas College of Pharmacy, Mangalore-574 143, India
30 January, 2012
15 March, 2012
28 April, 2012
01 May, 2012